What reason causes vitiligo

Disease analysis: The etiology of vitiligo is not completely understood at present. Currently, it is mainly considered to be related to the following factors, including autoimmune factors, genetic factors and neuropsychiatric factors.

One, the main cause

1, autoimmune factors: the occurrence of the disease is also closely related to autoimmune, when the patient's autoimmune decline, body cells can produce their own melanocyte antibodies, resulting in a reduction in melanin production, the formation of vitiligo. In addition, this disease may co-exist with autoimmune diseases such as hyperthyroidism.

2, melanocyte self-destruct factors: the disease appears in the exposure and pigment deepening parts, epidermal melanocytes hyperfunction, so that its depletion and decline, and may be caused by excessive or accumulation of melanocytes synthesis of intermediates. Experiments have confirmed that phenols or catecholamines, such as normal melanocyte damage. Due to occupational factors, such as exposure to or absorption of the above chemicals, can induce blemish.

3. Neurochemical factors: about 2/3 of patients' onset is associated with the development of skin lesions, mental trauma, overwork and anxiety. Some blemelee lesions are symmetrical or distributed along the ganglia, which may be related to the increase of neurochemical substances around melanocytes to damage melanocytes or inhibit melanin formation, indicating that neuropsychiatric factors are closely related to the occurrence of vitiligo.

4, genetic factors: the disease has genetic quality of the individual, under the stimulation of a variety of internal and external factors, can appear immune function, neuropsychiatric and endocrine metabolism and other functional disorders, leading to tyrosinase system inhibition or melanocyte destruction, ultimately make the disease pigment loss.

2. Inducing factors

There are various opinions on the inducing factors of vitiligo. Combined with various opinions, it is generally believed that the inducing factors are individuals with genetic quality. Under the stimulation of various internal and external factors, such as emotion and chemistry, it is shown as the disorders of immune function, neuropsychiatric and endocrine and metabolic functions, which lead to the inhibition of enzyme system, the destruction of melanocytes, or the generation or melanosis of melansome. Resulting in loss of pigment.