Vitiligo Patients Should do What Histopathological Examination?

The histopathological examination is a pathomorphological method to examine the pathological changes in organs, tissues, or cells of the body. In order to explore the disease process occurring in organs, tissues, or cells, a certain pathomorphological examination method can be used to examine the lesions occurring in them, to explore the causes of the lesions, the pathogenesis, the process of lesion development, and finally to make a pathological diagnosis. The pathomorphological examination method, first observes the pathological changes of the large specimen, then cut a certain size of lesion tissue, using pathological histological methods to make pathological sections, with a microscope to further examine the lesion.

Vitiligo is a local pigmentation loss caused by the disorder of melanin metabolism. The histopathological examination of vitiligo is generally without inflammatory reaction except for the decrease or loss of the number of melanocytes and melanin granules in the basal layer, and histopathological sectioning is not necessary for general.

Histopathological examination can be considered mainly in the following two cases; for pigment loss spots suspected to be vitiligo, when the diagnosis cannot be confirmed after long-term follow-up observation, or when malignant changes are suspected; for white patches that have been ineffective for a long time, when it is neither clear that they are completely white patches, and the patient urgently wants to treat them, histopathological examination (dopa) positive melanocytes can be considered to estimate the efficacy of new therapies.

It is necessary to do some tests before the treatment of vitiligo, from which abnormalities or potential visceral lesions can be detected and the causes identified, which can improve the cure rate and facilitate the recovery of vitiligo disease. Generally, the skin CT test, immune abnormalities test, trace elements test, wood lamp test, blood test, etc. can be a more comprehensive detection of vitiligo.