What's the Function of Immune Factors in the Course of Onset of Vitiligo?

It is found that there is a delicate relationship between Vitiligo and immune for people’s further study of immunology. From the biopsies of Vitiligo of the skin with raised white patches along the margin, the vitiligo white patches’ margin under evolution period and halo nevus, researchers found Lymphocyte or monocyte infiltration which are related to the function of immune.

There is anti-melanocytes antibody accompanying changes of other immune index in the blood of vitiligo patients. The incidence possibility of patients is higher than that of normal people, they are vitiligo patients with autoimmune diseases as systemic lupus erythematosus, autoimmune thyroiditis,etc. Or patients of autoimmune diseases with vitiligo.

In addition, there are isomorphic reaction in vitiligo patients which is considered as a kind of immune phenomenon. Most Vitiligo patients can achieve therapeutic effect under glococorticoid therapy, the abnormal immune index in blood will disappear, become better or recover with the improvement of white patches.

Usually, vitiligo patients accompany two autoimmune disorders.

Humoral Immunity Change. According to related literature reports, anti-parietal cell antibody, anti-smooth muscle antibody can be detected in the blood of vitiligo patients, as well as anti-melanocytes antibody,etc.

Cellular Immune Change. It shows that abnormal changes exist in T lymphocyte and its sub-group during the lymphocyte transformation test and natural spot formation test. All these manifest that vitiligo patients’ cellular immune is abnormal.