The Relationship Between Endocrine and Vitiligo

The endocrine system has several effects on pigment metabolism, which are listed in the following passages:

1. Melatonin factors:

Melatonin is mainly secreted by the pineal gland. The secretory function of the pineal gland is closely related to light, and prolonged light can inhibit melatonin.

2. Adrenaline and noradrenaline:

Adrenaline and adrenaline is the hormone secreted by the adrenal medulla, they secrete very little in a quiet state and encounter cold, pain, and emotional factors that make the body is "tension", in sympathetic excitement at the same time, the adrenal medulla secretion increased, so the two hormones increased. A small amount of adrenaline can inhibit the effect of melanocyte stimulation on isolated frog skin melanocytes.

3. Melanocyte stimulating hormone:

Recent studies have shown that human melanocyte-stimulating hormone may be secreted by the cells of the anterior pituitary gland that secrete hematopoietic. Melanocyte-stimulating hormone is divided into two kinds: a and β. When the patient receives a large amount of melanocyte-stimulating hormone treatment, local pigmentation will occur in the short term.

4.Dermatopoietin:

Dermatopoietin is secreted by the anterior pituitary gland. This may be due to the fact that hematopoietic contains a melanin-stimulating hormone, and there are also reports of using hematopoietic to treat vitiligo.

5. Thyroxine:

Thyroxine is secreted by the thyroid gland. The thyroid preparations in thyroxine, double iodine thyroxine is a complex of inorganic iodide, which can make the skin color lighter, but has no effect on frog melanocytes. In addition, it is not uncommon to see cases of hyperthyroidism with vitiligo, and when they remove the thyroid gland, individual vitiligo patients will have changes.

6. Sex hormones:

Sex hormones include male hormones and female hormones, male hormones are represented by testosterone, such as testosterone propionate; female hormones such as progesterone and estrogen. Sex hormones have the effect of deepening skin color, for example, pregnant women are often accompanied by facial chloasma and nipples, areolas, and other places where the color deepens, which is due to the increase of female hormones in pregnant women. For example, patients with liver disease have skin pigmentation and facial chloasma (also known as liver spots), which is due to the diminished function of inactivating hormones in patients with liver disease, resulting in an increased concentration of estrogen in the blood.

7. Corticosteroids:

Prednisone, dexamethasone, and cyano-cortisone are secreted by the adrenal cortex, and their effect on melanin metabolism is mainly related to melanocyte stimulation. Under normal conditions, the level of melanin-stimulating hormone and corticosteroid hormone in the blood is relatively balanced, and once it is out of balance, it affects the skin color. We have found that vitiligo patients taking prednisone treatment for arthritis after the expansion and increase of white spots.