The Appearance of Vitiligo Is Actually Caused by Inflammation

Vitiligo belongs to a primary depigmentation disease, and the white spot caused by inflammation belongs to secondary depigmentation. Obviously, there's a clear difference. However, clinically, some patients suffer from vitiligo after a cold, fever, and sore throat, or those diseases accelerate the development of vitiligo. There are also patients who develop white spots on the skin lesions after infection with the virus, and sometimes on the normal skin between the lesions. This is mainly because inflammation causes local nerve cell damage in the patient's body or causes the body to produce stress response, triggering the body's local or systemic immune or endocrine dysfunction, and finally induced vitiligo. In addition, there are some patients suffering from eczema, urticaria and other allergic skin diseases, their appearance of vitiligo is mainly because of immune dysfunction

There Are Several Causes of Inflammatory Vitiligo.

1. Part of the skin inflammatory response can induce the production of anti-melanocyte antibodies, resulting in damage or disappearance of a large number of normal melanocytes in the epidermis

2. Inflammation leads to liquefaction degeneration of basal cells, which in turn leads to impaired melanocyte function.

3. In vitiligo patients with evolution period, local inflammation of the skin occurs due to harmful external stimulation. Various bacteria, viruses and fungi can release a variety of inflammatory mediators and cytokines that cause damage to melanocytes

4.Some chronic inflammation leads to hyperplasia of the stratum corneum on the skin surface, thickening of the epidermis, poor contact between melanocytes and keratinocytes, obstruction of the transport and degradation of melanocytes, and decline or death of melanocytes