Vitiligo is Caused by what ＂Mysterious＂ Factors

Clinically, many patients have missed their best diagnosis and treatment time because they did not choose to do so when vitiligo first occur. There are multiple causes of vitiligo, but the direct cause is the graduate reduction or loss of melanin production capacity of melanocytes in the patient's body. This direct cause is mainly related to the following factors.

1. Melanocyte self-destruction factor.

2. Endocrine factors.

3. Psychological, neurological, and chemical factors.

4. Autoimmune factors.

5. Free radical damage factors.

6. Oxidative stress factors.

7. Relative deficiency of tyrosinase.

8. Genetic factors.

There are some triggering factors that are not known. The following let us uncover the "mysterious" factors that trigger vitiligo.

The occurrence of vitiligo is closely related to mental factors. In the research within a certain number of vitiligo patients, some researcher found that whether the vitiligo of their patients is in the early, stable, recovering stages, or even have recovered, if they receive or receive again some mental trauma, brain overload, or stress, etc. it could cause the white patches to expand, increase or recur in these patients.

Local nerve damage can also induce the occurrence of vitiligo. The patient's white patches are distributed in bands or strips along the nerve segments or dermatomes, and sometimes the white patches also appear after herpes zoster along the corners of the mouth to the jaw angle, and the patient is accompanied by local sensory dullness. Vitiligo has been reported to occur in areas innervated by injured brachial plexus nerve fibers. In segmental vitiligo, the distribution of the lesions is segmental, involving one or several nerve segments, not crossing the midline of the body, with a unilateral distribution. It has been found that there are nerve fibers in segmental vitiligo that reach into the melanocytes at the junction of the white spots and normal skin, which is not seen in normal skin.

Central nervous system lesions can trigger vitiligo. A lot of information shows that some infectious diseases such as syphilis, and leprosy, will not only cause neurological damage but also be accompanied by skin color changes. The skin color changes are also related to central nervous system lesions, such as multiple sclerosis patients can also have hypopigmented skin patches like vitiligo.